Prof. Mannelli

Endocrinologo

  • Disturbi delle ghiandole surrenali
  • Disturbi della ghiandola tiroidea
  • Ipofisi
  • Tumore alla tiroide
  • Tumore Surrene

Prof. Massimo Mannelli

Nº albo dei medici: 4652


Il Prof. Mannelli è esperto in Endocrinologia a Firenze.
Si è laureato in Medicina e Chirurgia presso l’Università degli Studi di Firenze nel 1973 ed ha conseguito le specializzazioni in Malattie dell'Apparato Cardiovascolare nel 1976 ed in Endocrinologia e Malattie del Ricambio nel 1979. È stato Medico Assistente, Responsabile di Programma e Coordinatore nel Dipartimento Medico Geriatrico presso l’Azienda Ospedaliero-Universitaria Careggi di Firenze, prima di diventare nel 2016 Responsabile dell’Unità Complessa di Endocrinologia, ruolo questo che ha ricoperto fino alla fine di Ottobre 2018. È stato Professore Ordinario di Endocrinologia presso l’Università degli Studi di Firenze. Fa parte di numerose società mediche tra le quali la Società Italiana di Endocrinologia (SIE), la Società Europea di Endocrinologia (ESE), l'Associazione Medici Endocrinologi Italiana (AME). È autore di più di 200 articoli su riviste scientifiche internazionali e almeno 50 capitoli di libri, oltre a peer-reviewed per un impact factor superiore a 1000. Ha un numero di citazioni superiore a 16.000 (Google Scholar) ed un h-index di 54 (Google Scholar). Nella sua carriera si è focalizzato nella diagnosi e nel trattamento delle patologie che colpiscono il surrene, la tiroide, l’Ipofisi, così come i disturbi Idroelettrolitici e l’ipertensione di origine endocrina.
  • Esperienza Professionale

    • Responsabile dell’Unità Complessa di Endocrinologia presso l’Azienda Ospedaliera Universitaria Careggi, 2016-2018.
    • Coordinatore delle Attività Didattiche e di Ricerca del Dipartimento Medico-Geriatrico presso l’Azienda Ospedaliera Universitaria Careggi, 2016-2018.
    • Coordinatore delle Attività Didattiche e di Ricerca del Dipartimento Medico-Geriatrico presso l’Azienda Ospedaliera Universitaria Careggi, 2016-2018.
    • Medico Assistente di Ruolo nel Servizio di Endocrinologia presso l’Azienda USL 10 di Firenze, 1984-1992.
    • Medico Assistente nel Servizio di Endocrinologia presso l’Azienda USL 10 di Firenze, 1979-1984.
    • Dirigente Medico presso l'Unità di Endocrinologia della Azienda Ospedaliera Careggi 1992-2004
    • Libero Professionista presso l’Azienda Ospedaliero-Universitaria Careggi di Firenze, fino al 31 Ottobre 2018. Libero Professionista dal 1 Novembre 2018
  • Cariche in enti pubblici e privati

    • Fondatore dell'European Network for the Study of the Adrenal Tumors, 2003-oggi.
    • Referente del Ministero della Sanità per l’Educazione Continua in Medicina, 2001-2007.
    • Coordinatore del Gruppo di Studio sul Feocromocitoma della Società Italiana di Endocrinologia, 1996-1999.
    • Coordinatore del Comitato Qualità della Società Italiana di Endocrinologia, 1995 -1999.
    • Coordinatore della Commissione Scientifica della Società Italiana di Endocrinologia 2003-2005
    • Membro della Commissione Didattica della Società Italiana di Endocrinologia, 1995-2001
    • Membro della Commissione Didattica della Società Italiana di Endocrinologia 1995-2001
    • Membro del Consiglio Direttivo della SIE 2000-2003
    • Direttore della Scuola di Specializzazione in Endocrinologia e Malattie del Metabolismo, Università di Firenze 2010-2015
    • Redattore associato del giornale della SIE l'Endocrinologo, 2000-2004.
    • Coordinatore del Club Surrene della SIE 2010-2016
    • Coordinatore del Registro Toscano delle Malattie Rare Endocrinologiche 2010-oggi
  • Risultati accademici salienti

    • Laurea in Medicina e Chirurgia presso l’Università degli Studi di Firenze, 1973.
    • Specializzazione in Malattie dell’Apparato Cardiovascolare presso l’Università degli Studi di Firenze, 1976.
    • Specializzazione in Endocrinologia presso l’Università degli Studi di Firenze, 1979.
  • Membro di società scientifiche

    • Membro dell’European Council for Blood Pressare and Cardiovascular Research, 2006-2018.
    • Membro della The Endocrine Society, 2003-2017.
    • Membro della Medical Research Society, 1990-1993.
    • Membro della Società Italiana dell'Ipertensione Arteriosa, 1990-1993.
    • Membro della Società Italiana di Endocrinologia, 1984-oggi.
    • Membro della European Society of Endocrinology 2006-oggi
    • Membro della European Neuroendocrine Association 2009-2017
  • Docenze

    • Docente di Endocrinologia nel Dipartimento di Scienze Biomediche Sperimentali e Cliniche presso l’Università degli Studi di Firenze, 1992-2018.
  • Pubblicazioni e conferenze

    • PROF. MASSIMO MANNELLI Scientific Papers on Peer-Reviewed Journals 1) P. Giannotti, M. Mannelli, G. Fiorelli, M. Serio. Radioimmunoassay of plasma aldosterone. J Nucl Biol Med 18: 104-111, 1974 (0.313) 2) L. Borsi, M. Mannelli, U. Barbieri, P. Giannotti, M. Serio. Measurement of urinary free cortisol and its clinical application. J Nucl Biol Med 20: 160-164, 1976. (0.313) 3) F. Mannelli, F. Bassi, M. Mannelli, M. Serio. Radioimmunoassay of human luteinizing hormone: bias due to antisera. J Nucl Biol Med 21: 18-22, 1977. (0.313) 4) F. Fantini, C.R. Lucchini, L. Padelletti, A. Marsili, P. Dolara, M. Mannelli. Digoxin and congestive heart failure. Acta Cardiologica XXXII, 5:353-362, 1977. (0.311) 5) G. Forti, A. Borghi, G. Giusti, M. Pazzagli, P. Giannotti, M. Mannelli, S. Fusi, M. Serio. Klinefelter' syndrome: effects of short term testosterone administration on hypothalamic-pituitary axis function. J Endocrinol Invest 2: 239-244, 1978. (1.621) 6) G. Forti, G. Giusti, A. Borghi, M. Pazzagli, G. Fiorelli, E. Calabresi, M. Mannelli, F. Bassi, P. Giannotti, S. Fusi, M. Serio. Klinefelter' syndrome: a study of its hormonal plasma pattern. J Endocrinol Invest 2: 149-154, 1978. (1.621) 7) M. Mannelli, D. Borrelli, P. Gonnelli, G. Fiorelli, G. Forti, M. Serio. 17Beta Oestradiol concentration in spermatic venous blood with incresing age. Int J Androl 2: 131-135, 1979. (1.422) 8) M. Serio, P. Gonnelli, D. Borrelli, A. Pampaloni, G. Fiorelli, E. Calabresi, G. Forti, M. Pazzagli, M. Mannelli, A. Baroni, P. Giannotti, G. Giusti. Human testicular secretion with increasing age. J Steroid Biochem II: 893-897, 1979. (1.968) 9) G. Forti, G. Giusti, M. Pazzagli, G. Fiorelli, D. Borrelli, P. Cicchi, R. Guazzelli, C. Conti, G. Scarselli, M. Franchini, R. Boninsegni, M. Mannelli, M. Serio. Spermatic and peripheral oestradiol levels in patients affected by azoospermia due to tubular damage. Int J Androl 4: 161-171, 1981. (1.422) 10) M. Mannelli, R.G. Gheri, C. Selli, D. Turini, A. Pampanini, G. Giusti, M. Serio. A study of human adrenal secretion. Measurement of epinephrine, norepinephrine, dopamine and cortisol in peripheral and adrenal venous blood under surgical stress. J Endocrinol Invest 5: 91-95, 1982. (1.621) 11) G.G. Neri-Serneri, G. Masotti, G.F. Gensini, L. Poggesi, R. Abbate, M. Mannelli. Prostacyclin and tromboxane A2 formation in response to adrenergic stimulation in humans: a mechanism for local control of vascular response to simpathetic activation? Cardiovasc Res 15: 285-295, 1981. (3.092) 12) M. Serio, C. Orlando, P. Giannotti, M. Mannelli, G. Messeri. The importance of the quality of the method in endocrinological diagnosis. J Nucl Med Allied Sci 26: 327-331, 1982. (0.313) 13) Porciani MC, G. Barletta, M. Mannelli, F. Bellandi, G. Morace. Pheochromocytoma presenting as possible cardiomyopatia. G Ital Cardiol 12: 826-830, 1982. 14) Mannelli M, Maggi M, DeFeo ML, Cuomo S, Forti G, Moroni F, Giusti G. Naloxone administration releases catecholamines. N Engl J Med 1983; 308: 654-655. (28.857) 15) G. Delitala, M. Maioli, A. Pacifico, S. Brianda, M. Palermo, M. Mannelli. Cholinergic receptor control mechanisms for L-Dopa, apomorphine and clonidine-induced growth hormone secretion in man. J Clinical Endocrinol Metab 57: 1145-1149, 1983. (5.873) 16) R.G. Gheri, M. Mannelli, M.L. DeFeo, C. Mantelacchi, M. Maggi, S. Cuomo. Plasma catecholamine response to hortostasis in longstanding hypothiroidism. Boll Soc Ital Biol Sperim 59: 1868- 1871, 1983. 17) M. Mannelli, R.G. Gheri, M.L. DeFeo, C. Malentacchi, M. Serio. Effects of thyroid replacement therapy on catecholamine plasma levels. J Endocrinol Invest 6: 307-309, 1983. (1.621) 18) G.G Neri-Serneri, G. Masotti, S. Castellani, L. Scarti, F. Trotta, M. Mannelli Role of the PGE2 in the modulation of the adrenergic response in man. Cardiovasc Res 17: 662-670, 1983. (3.092) 19) M. Mannelli, G. Delitala, M.L. Defeo, M. Maggi, S. Cuomo, M. Piazzini, R. Guazzelli, M. Serio. Effects of different dopaminergic antagonists on bromocriptine-induced inhibition of norephinephrine release. J Clin Endocrinol Metab 59: 74-78, 1984. (5.873) 20) G. Laffi, G. la Villa, M. Pinzani, M. Mannelli, G. Buzzelli, S. Paladini, A. Pampana, C. Smorlesi, G. Pedretti, P. Gentilini. Vasoactive factors in the mechanism of renal sodium handling in cirrhotics: The effect of acute plasma expansion. Pharmacol Res Comm 16: 613-635, 1984. 21) G. La Villa, G. Laffi, M. Pinzani, A. Pampana, M. Mannelli, C. Smorlesi, P. Gentilini. Vasoactive factors in decompensated cirrhosis. Effect of acute plasma expansion. Boll Soc Ital Biol Sperim 60: 535-541, 1984. 22) G. Delitala, M. Boscaro, M. Mannelli, G. Merola, M. Maggi, M.L. DeFeo. Opiates and ACTH-cortisol-axis in man. Riv It Biol Med 4: 35, 1984. 23) M. Mannelli, M. Maggi, M.L. DeFeo, S. Cuomo, G Delitala, G. Giusti, M. Serio. Effects of naloxone on catecholamine plasma levels in adult men. A dose-response study. Acta Endocrinol 106: 357-361, 1984. (2.421) 24) M. Maggi, M.L. De Feo, M. Mannelli, G. Delitala, G. Forti. Naloxone administration does not affect gonadotrophin secretion in males patients with isolated hypogonadotrophic hypogonadism. Acta Endocrinol 109: 153-157, 1985. (2.421) 25) M. Mannelli, M.L. DeFeo, M. Maggi, A. Salvetti, G. Giusti, M. Serio. Does endogenous dopamine modulate human sympathetic activity through DA2 receptors? Eur J Clin Pharmacol 29:159-164, 1985. (1.771) 26) M. Mannelli, M. Maggi, M.L. De Feo, M. Boscaro, G. Opocher, F. Mantero, E. Baldi, G. Giusti. Opioid modulation of normal and pathological chromaffin tissue. J Clin Endocrinol Metab 62: 577-582, 1986. (5.873) 27) G. Laffi, G. La Villa, M. Pinzani, G. Ciabattoni, P. Patrignani, M. Mannelli, F. Cominelli, P. Gentilini. Altered renal and platelet arachidonic acid metabolism in cirrhosis. Gastroenterology 90: 274-282, 1986. (12.182) 28) M. Mannelli, M.L. De Feo, M. Maggi, P. Geppetti, E. Baldi, C. Pupilli, M. Serio. Effect of verapamil on catecholamine secretion by human pheochromocytoma. Hypertension 8: 813-814, 1986 (letter). (5.630) 29) A. Grossman, G. Delitala, M. Mannelli, S. Al-Damluji, D.H. Coy , G. M. Besser. An analogue of met-enkephalin attenuates the pituitary-adrenal response to ovine corticotrophin releasing factor. Clin Endocrinol 25: 421-426, 1986. (2.833) 30) F. Franchi, P. Lo Sapio, G. Strazzulla, G. Fabbri, A. Scardi, M. Pinzani, G. Laffi, M. Mannelli. Acute effect of furosemide on renal kallikrein and prostaglandin systems in mild to moderate essential hypertension. Int J Clin Pharmacol Ther Tox 25: 44-49, 1987. (1,299) 31) M. Mannelli, M.L. De Feo, M. Maggi, C. Pupilli, G. Opocher, T. Valenza, E. Baldi, M. Serio. Usefulness of basal catecholamine plasma levels and clonidine suppression test in the diagnosis of pheochromocytoma. J Endocrinol Invest 10: 377-382, 1987. (1.621) 32) E. Baldi, M.L. De Feo, P. Geppetti, V. Carla', M. Maggi, C. Pupilli, M.G. Spillantini, A. Brocchi, M. Mannelli. Measurement of catecholamine, met-enkephalin, somatostatin and substance P-like immunoreactivities in 12 human pheochromocytomas. J Endocrinol Invest 11: 133-138, 1988. (1.621) 33) M. Mannelli, C. Pupilli, G. Fabbri, R. Musante, M.L. De Feo, F. Franchi, G. Giusti. Endogenous dopamine (DA) and DA2 receptors: a mechanism limiting excessive sympathetic-adrenal discharge in humans. J Clin Endocrinol Metab 66: 626-631, 1988. (5.873) 34) E. Baldi, C. Pupilli, F. Amenta, M. Mannelli. Presence of dopamine-dependent adenylate cyclase activity in human renal cortex. Eur. J. Pharmacol. 149: 351-356, 1988. (2.047) 35) P. Geppetti, E. Baldi, S. Manzini, E. Del Bianco, A. Maggi, A. Natali, M. Mannelli. Regional differences of adenylate cyclase stimulation by calcitonin and calcitonin gene-related peptide in the human kidney. J. Clin. Endocrinol. Metab. 69: 491-495, 1989. (5.873) 36) M. Mannelli. Diagnostic problems in pheochromocytoma J. Endocrinol. Invest. 12: 739-757 ,1989 (Review Article). (1.621) 37) M. Mannelli, C. Pupilli, R. Lanzillotti, L. Ianni, F. Amenta, A. Ricci, M. Serio. Dopamine modulation of pathological human chromaffin tissue. Am. J. Hypertens. 3 (suppl.): 22S-24S, 1990. (2.083) 38) M. Mannelli, C. Pupilli, R. Lanzillotti, L. Ianni, M. Serio. Catecholamines and blood pressure regulation. Horm. Res. 34:156-160, 1990. (1.717) 39) M. Mannelli, R. Lanzillotti, L. Ianni, C. Pupilli, M. Serio. Dopaminergic modulation of human adrenal medulla: indirect evidence for the involvement of DA2 receptors located on the chromaffin cells. J. Auton. Pharmacol. 10 (suppl. 1): 79-84, 1990. (0.735) 40) C. Fronzaroli, G. La Villa, G. Strazzulla, M. Mannelli, F. Franchi. Renal effects of atrial natriuretic peptide during dopa- decarboxylase inhibition in patients with essential hypertension. Eur. J. Clin. Pharmacol. 44: 423-427, 1993. (1.771) 41) M: Mannelli, C. Pupilli, R. Lanzillotti, L. Ianni, A. Amorosi, G. Credi, C. Pratesi. A non-secreting pheochromocytoma presenting as an incidental adrenal mass. Report on a case. J. Endocrinol. Invest. 16:817-822, 1993. (1.621) 42) M. Marinoni, A. Ginanneschi, D. Inzitari, M. Mannelli, P.A. Modesti, L. Amaducci. Impaired cerebral autoregulation in patients with Shy-Drager syndrome. Int J Angiol 2: 12-15, 1993. 43) M. Mannelli, R. Lanzillotti, C. Pupilli, L. Ianni, A. Conti, M. Serio. Adrenal medulla secretion in Cushing's syndrome. J Clin Endocrinol Metab. 78: 1331-1335, 1994. (5.873) 44) C. Pupilli, R. Lanzillotti, G. Fiorelli, C. Selli, R.A. Gomez, R.M. Carey, M. Serio, M. Mannelli. Dopamine D2 receptor gene expression and binding sites in adrenal medulla and pheochromocytoma. J Clin Endocrinol Metab. 79: 56-61,1994. (5.873) 45) C. Pupilli, M. Brunori, N. Misciglia, C. Selli, L. Ianni, M. Yanagisawa, M. Mannelli, M. Serio. Presence and distribution of endothelin-1 (ET-1) gene expression in human kidney. Am J Physiol. 267: F679-F687, 1994. (3.590) 46) A. Piccioli , G. Chini, M. Mannelli, M. Serio. Bilateral massive adrenal hemorrhage due to sepsis: report of two new cases. J Endocrinol Invest. 17:821-824, 1994. (1.621) 47) F. Barontini, F. Ammannati, R. Gagliardi, S. Maurri, M. Mannelli, P. Mennonna. A further case of giant intrasellar carotid aneurysm mimicking a pituitary adenoma: the relevance of a multivariate approach in differential diagnosis. Ital J Neurol Sci. 15: 369-372, 1994. (1,435) 48) L. Quadro, L. Panariello, D. Salvatore, F. Carlomagno, M. Del Prete, V. Nunziata, V. Colantuoni, G. Di Giovanni, M.L. Brandi, M. Mannelli, R. Gheri, U. Verga, A. Libroia, N. Berger, A. Fusco, M. Grieco, M. Santoro. Frequent RET Protooncogene mutations in Multiple Endocrine Neoplasia Type 2A. J Clin Endocrinol Metab 79: 590-594, 1994. (5.873) 49) M. Mannelli, C. Pupilli, R. Lanzillotti, L. Ianni, F. Bellini, M. Serio. Role for endogenous dopamine in modulating sympathetic-adrenal activity in humans. Hypertension Research, 18 (Suppl. 1): S79-S86, 1995. (3.144) 50) C. Lazzeri, F. Franchi, C. Porciani, C. Fronzaroli, V. Casini Raggi, M.L. De Feo, M. Mannelli, R.M. Cersosimo, G. La Villa. Systemic hemodynamics and renal function during brain natriuretic peptide infusion in patients with essential hypertension. Am J Hypertens 8: 799-807, 1995. (3.122) 51) G. Laffi, A. Lagi, M. Cipriani, G. Barletta, L. Bernardi, L. Fattorini, L. Melani, D. Riccardi, G. Bandinelli, M. Mannelli, G. La Villa, P. Gentilini. Impaired cardiovascular autonomic response to passive tilting in cirrosis with ascites. Hepatology 24:1063-1067, 1996. (7.344) 52) V. Briganti, M. Mannelli, G. La Cava, A. Peri, U. Meldolesi, R. Masi, A. Pupi. Characterization of an ectopic secreting carcinoid with 111 In-[DTPA-D-Phe]-Pentatreotide. J Nucl Med.38: 711-714, 1997. (3.326) 53) M. Mannelli, C. Lazzeri, L. Ianni, G. La Villa, C. Pupilli, F. Bellini, M. Serio. Dopamine and sympathoadrenal activity in man. Clin Exp Hypert. 19: 163-179, 1997. (1.171) 54) M.L. De Feo, G. La Villa, C. Lazzeri, C. Tosti-Guerra, A. Becorpi, C. Pupilli, M. Mannelli. Urinary Endothelin-1 excretion is enhanced by low-dose infusion of brain natriuretic peptide in normal man. Hypertension 29: 70-74, 1997. (5.630) 55) C. Pupilli, P. Romagnani, L. Lasagni, F. Bellini, N. Misciglia, N. Emoto, M. Yanagisawa, M. Rizzo, M. Mannelli, M. Serio. Localization of endothelin-converting enzyme-1 in human kidney. Am J Physiol 273: F749-F756, 1997 (3.590) 56) A. Del Rosso, G. Fradella, L. Russo, P. Bartoli, F. Bonechi, A. Brandinelli, M. Maioli, F. Mazza, M. Sansoni, A. Zipoli, M. Mannelli, A. Ieri. Pheochromocytoma crisis caused by contemporary ergotamine, caffeine and nimesulide administration. Am J Med Sci 314:396-398, 1997 (1.217). 57) G. Barletta, C. Lazzeri, S. Vecchiarino, R. Del Bene, G. Messeri, A. Dello Sbarba, M. Mannelli, G. La Villa. Low-dose C-type natriuretic peptide does not affect cardiac and renal function in man. Hypertension 31:802-808, 1998 (5.630) 58) F. Bellini, L. Sammicheli, L. Ianni, C. Pupilli, M. Serio, M. Mannelli. Hypoglycemia unawareness in a patient with dumping syndrome: report on a case. J Endocrinol Invest 21: 463-467, 1998 (1.621) 59) G. La Villa, M. Mannelli, C. Lazzeri, S. Vecchiarino, M.L. De Feo, C. Tosti-Guerra, R. Bandinelli, F. Franchi. Different effects of atrial and C-type natriuretic peptide on the renal release of endothelin-1 in man. Clin Sci 95: 595-602, 1998 (1.941) 60) C. Lazzeri, G. La Villa, M. Mannelli, L. Ianni, G. Barletta, N. Montano, F. Franchi. Effects of clonidine on power spectral analysis of heart rate variability in mild essential hypertension. J Auton Nerv Syst 74:152-159, 1998 (2.895) 61) C. Lazzeri, G. La Villa, M. Mannelli, L. Ianni, F. Franchi. Effects of acute clonidine administration on power spectral analysis of heart rate variability in healthy humans. J Auton Pharmacol 74: 152-159, 1998 (0.735) 62) C. Pupilli, L. Lasagni, P. Romagnani, F. Bellini, M. Mannelli, N. Misciglia, C. Mavilia, U. Vellei, D. Villari, M. Serio. Angiotensin II stimulates the synthesis and secretion of vascular permeability factor/vascular endothelial growth factor in human mesangial cells. J Am Soc Nephrol. 10: 242-255, 1999 (6.404) 63) M. Mannelli, L. Ianni, c. Lazzeri, W. Castellani, C. Pupilli, G. La Villa, G. Barletta, M. Serio, F. Franchi. In vivo evidence that endogenous dopamine modulates sympathetic acyivity in man. Hypertension 34: 398-402, 1999. (5.630). 64) M. Mannelli, L. Ianni, A. Cilotti, A. Conti. Pheochromocytoma in Italy: a multicentric retrospective study. Eur J Endocrinol. 141: 619-624, 1999 (2.560). 65) Mannelli M, Gelmini S, Arnaldi G, Becherini, L, Bemporad D, Crescioli C, Pazzagli M, Mantero F, Serio, M, Orlando C. Telomerase activity is significantly enhanced in malignant adrenocortical tumors in comparison to benign adrenocortical adenomas. J Clin Endocrinol Metab. 2000; 85: 468-470. (5.873). 66) H. Le Hir, N. Charlet-Berguerand, AP. Gimenez-Roqueplo, M. Mannelli, PF: Plouin, V. de Franciscis, and C. Thermes. Relative expression of the RET9 and RET51 isoforms in human pheochromocytomas. Oncology 58:311-318, 2000 (2.330). 67) M. Tommasi, A. Brocchi, A. Cappellini, S. Raspanti, U. Meldolesi, M. Mannelli. False increase in serum calcitonin using a non-competitive two-site irma assay. J Endocrinol Invest. 24: 356-360, 2001 (1.621) 68) F. Franchi, C. Lazzeri, G. Barletta, L. Ianni, M. Mannelli. Centrally mediated effects of bromocriptine on cardiac sympatho-vagal balance. Hypertension 38: 123-129, 2001 (5.630) 69) G. Eisenhofer, MM Walther, TT Huynh, S Li, SR Bornstein, M. Mannelli, DS Goldstein, A Vortmeyer, JWM Lenders, WMLinehan, K Pacak. Pheochromocytomas in von-Hippel Lindau disease and Multiple Endocrine Neoplasia Type 2 display distinct noradrenergic and adrenergic phenotypes. J Clin Endocrinol Metab 86: 1999-2008, 2001 (5.873) 70) A. Valeri, A. Borrelli, L. Presenti, M. Lucchese, F. Venneri, M. Mannelli, S. Regio, D. Borrelli. Adrenal masses in neoplastic patients. The role of laparoscopic procedure. Surg Endosc 15: 90-93, 2001 (2.057) 71) Peri A, Luciani P, Conforti B, Baglioni-Peri S, Cioppi F, Crescioli C, Ferruzzi P, Gelmini S, Arnaldi G, Nesi G, Serio M, Mantero F, Mannelli M. Variable expression of the transcription factors cAMP response element-binding-protein and inducible cAMP early repressor in the normal adrenal cortex and in adrenocortical adenomas and carcinomas. J Clin Endocrinol Metab. 2001; 86: 5543-5549 (5.873) 72) A. Peri, D. Bemporad, G. Parenti, P. Luciani, M. Serio, M. Mannelli. Cushing’s syndrome due to an intermittent ectopic ACTH production showing a temporary remission during a pulmonary infection. Eur J Endocrinol. 145: 605-611, 2001 (2.560). 73) M.L. Brandi, RF Gagel, A. Angeli, JP Bilezikian, P. Beck-Peccoz, C. Bordi, B. Conte-Devolx, A. Falchetti, R.G. Gheri, A. Libroia, C.J.M. Lips, G. Lombardi, M. Mannelli, F. Pacini, B.A. Ponder, F. Raue, B. Skogseid, G. Tamburrano, R.V. Thakker, N.W. Thompson, P. Tomassetti, F. Tonelli, S.A. Wells Jr, S. J. Marx. Guidelines for diagnosis and therapy of multiple endocrine neoplasia type 1 and 2. J Clin Endocrinol Metab. 2001; 86: 5658-5671. (5.641) 74) Lenders JW, Pacak K, Walther MM, Linehan WM, Mannelli M, Friberg P, Kaiser HR, Goldstein DS, Eisenhofer G. Biochemical diagnosis of pheochromocytoma: which test is best? JAMA 2002; 287:1427-1434. (21.455) 75) M. Mannelli, D. Bemporad. Diagnosis and management of pheocromocytoma in pregnancy. J Endocrinol Invest. 25: 567-571, 2002. (Review) (1.621) 76) GA. Fontana, Pantaleo T, Lavorini F, Bongianni F, Mannelli M, Bridge PD, Pistolesi M. Handgrip-induced airway dilation in asthmatic patients with bronchoconstriction induced by MCh inhalation. J Appl Physiol. Nov;93(5):1723-30, 2002. (2.720) 77) M. Mannelli. Pheochromocytoma: a permanent challenge for the clinical Endocrinologist. J Endocrinol Invest. 26: 387-388, 2003. (Editorial) (1.621) 78) G. La Cava, A. Imperiale, C. Olianti, R. Gheri, C. Ladu, M. Mannelli, A. Pupi SPECT semiquantitative analysis of adrenocortical 131I-6β-iodomethyl-norcholesterol uptake to discriminate subclinical and preclinical functioning adrenal incidentaloma. J Nucl Med 44: 1057-1064, 2003 (4.587) 79) M. Mannelli, P. Ferruzzi, P. Luciani, C. Crescioli, l. Buci, G. Corona, M. Serio, A. Peri. Cushing’s sindrome in a patient with bilateral macronodular adrenal hyperplasia responding to cisapride: an in vivo and in vitro study. J Clin Endocrinol Metab 88:4616-4622, 2003 (5.873) 80) Luciani P, Ferruzzi P, Arnaldi G, C. Crescioli, S. Benvenuti, G. Nesi, A. Valeri, I. Greve, M. Serio, M. Mannelli, A. Peri Expression of the novel ACTH-responsive gene seladin-1/DHCR24, in the normal adrenal cortex and in adrenocortical adenomas and carcinomas. J Clinical Endocrinol Metab. 2004; 89:1332-1339. (5.873) 81) Eisenhofer G, Huynh TT, Pacak K, F.M. Brouwers, M.M. Walther, W. M. Linehan, P.J. Munson, M. Mannelli, D.S. Goldstein, A.G. Elkahloun. Distinct gene expression profile in norepinephrine and epinephrine producing hereditary and sporadic pheochromocytomas: Activation of hypoxia-driven angiogenic pathways in von Hippel-Lindau syndrome. End-Rel Cancer. 2004; 11: 897-911. (8.894) 82) Ferruzzi P, Ceni E, Tarocchi M, Grappone C, Milani S, Galli A, Fiorelli G, Serio M, Mannelli M. Thiazolidinediones inhibit growth and invasiveness of the human adrenocortical cancer cell line H295R. J. Clin Endocrinol Metab. 2005; 90: 1332-9. (5.873) 83) L. Simi, R.Sestini, P. Ferruzzi, M.S. Gaglianò, F. Gensini, M.Mascalchi, L.Guerrini, C. Pratesi, P. Pinzani, G. Nesi, T. Ercolino, M. Genuardi, M. Mannelli. Phenotype variability of neural crest-derived tumours in six Italian families segregating the same founder SDHD mutation Q109X. J Med Genet 42: e52 2005. (6,368) 84) F M Brouwers, E F Petricoin, III, L Ksinantova, J Breza, V Rajapakse, S Ross, D Johann, M Mannelli, B L Shulkin, R Kvetnansky, G Eisenhofer, M M Walther, B A Hitt, T P Conrads, T D Veenstra, D P Mannion, M R Wall, G M Wolfe, V A Fusaro, L A Liotta and K Pacak Low molecular weight proteomic information distinguishes metastatic from benign pheochromocytoma. Endocrine-Related Cancer.2005; 12: 263-272. (5.193) 85) Rotondi M, Falorni A, De Bellis A, Laureti S, Ferruzzi P, Romagnani P, Buonamano A, Lazzeri E, Crescioli C, Mannelli M, Santeusanio F, Bellastella A, Serio M. Elevated serum interferon-{gamma} inducible chemokine IP-10/CXCL10 in autoimmune primary adrenal insufficiency and in vitro expression in human adrenal cells primary cultures after stimulation with proinflammatory cytokines. J Clin Endocrinol Metab. 90(4):23572357-63. 2005 (5.873) 86) Eisenhofer G, Lenders JWM, Goldstein DS, Mannelli M, Csako G, Walther MM, Brouwers FM, Pacak K. Pheochromocytoma catecholamine phenotypes and prediction of tumor size and location by use of plasma free metanephrines. Clin Chem.2005; 51:735-44. (5.538) 87) Terzolo M, Bovio S, Pia A, Conton PA, Reimondo G, Dall'asta C, Bemporad D, Angeli A, Opocher G, Mannelli M, Ambrosi B, Mantero F. Midnight serum cortisol as a marker of increased cardiovascular risk in patients with a clinically inapparent adrenal adenoma. Eur J Endocrinol. 153(2):307-15, 2005 (3.140). 88) Lenders JW, Eisenhofer G, Mannelli M, Pacak K. Phaeochromocytoma. Lancet. 2005; ;366:665-75.(21.713) 89) Imperiale A, Olianti C, Mannelli M, La Cava G, Pupi A. Tomographic evaluation of [(131)I] 6beta-iodomethyl-norcholesterol standardised uptake trend in clinically silent monolateral and bilateral adrenocortical incidentalomas. Q J Nucl Med Mol Imaging. 49: 287-96, 2005 (2.194). 90) Valeri A, Bergamini C, Manca G, Mannelli M, Presenti L, Peri A, Borrelli A, Tonelli P. Adrenal incidentaloma: the influence of a decision-making algorithm on the short-term outcome of laparoscopy. J Laparoendosc Adv Surg Tech A. 15: 451-9, 2005 (0.862). 91) G.P. Bernini, A. Moretti, M. Mannelli, T. Ercolino, M. Bardini, D. Caramella, C. Taurino, A. Salvetti. Unique association of non-functioning pheochromocytoma, ganglioneuroma, adrenal cortical adenoma, epatic and vertebral hem angiomas in a patient with a new intronic variant in the VHL gene. J Endocrinol Invest. 2005; 28: 1032-1037. (1.621) 92) Parenti G, Nassi R, Silvestri S, Bianchi S, Valeri A, Manca G, Mangiafico S, Ammannati F, Serio M, Mannelli M, Peri A. Multi-step approach in a complex case of Cushing's syndrome and medullary thyroid carcinoma. J Endocrinol Invest. 29: 177-81, 2006. (1.621) 93) Rossi GP, Bernini G, Desideri G, Fabris B, Ferri C, Giacchetti G, Letizia C, Maccario M, Mannelli M, Matterello MJ, Montemurro D, Palumbo G, Rizzoni D, Rossi E, Pessina AC, Mantero F. Renal Damage in Primary Aldosteronism. Hypertension. 48: 231-238, 2006 (5.630) 94) Mannelli M., Simi L., ErcolinoT., Gaglianò M.S, Becherini L., Vinci S., Sestini R., Gensini F, Pinzani P., Mascalchi M., Guerrini L., Pratesi C, Nesi G., Torti F., Cipollini F, Bernini G.P.,Genuardi M. : SDH mutations in PGL syndromes. Ann N Y Acad Sci. 2006; 1073: 183-189. (1,971) 95) Mannelli M. Management and Treatment of Pheochromocytomas and Paragangliomas. Ann N Y Acad Sci. 2006; 1073: 405-416. (1,971) 96) Rossi GP, Bernini G, Caliumi C, Desideri G, Fabris B, Ferri C, Ganzaroli C, Giacchetti G, Letizia C, Maccario M, Mallamaci F, Mannelli M, Mattarello MJ, Moretti A, Palumbo G, Parenti G, Porteri E, Semplicini A, Rizzoni D, Rossi E, Boscaro M, Pessina AC, Mantero F. The Primary Aldosteronism prevalence in hypertensives (PAPY Study): a prospective national survay. J Am Coll Cardiol; 48:2293-2300, 2006 (9.200) 97) Gimenez-Roqueplo AP, Lehnert H, Mannelli M, Neumann H, Opocher G, Maher ER, Plouin PF on behalf of the European Network for the Study of Adrenal Tumours (ENS@T) Pheochromocytoma Working Group. Phaeochromocytoma, New Genes and Screening Strategies. Clin Endocrinol,. 2006; 65: 699-705. (3.412) 98) Pacak K, Eisenhofer G, Ahlman H, Bornstein S, Gimenez-Requeplo AP, Grossman AB, Kimura N, Mannelli M, Mc Nicol AM, Tischler AS. Phaeochromocytoma: Recent advances, current approaches and recommendations for clinical practice from the First International Symposium on Pheochromocytoma. Nat Clin Pract Endocrinol Metab.2007;3:92-102. (3,678) 99) Moretti A, Minuto M, Berti P, Bernini GP, Mannelli M, Miccoli P. Unusual association of adrenal pheochromocytoma and para-aortic neurofibroma in pregnancy. J Endocrinol Invest. 29:738-41, 2006. (1,621) 100) Zogheri A, Di Mambro A, Mannelli M, Serio M, Forti G, Peri A. Hyponatremia and pituitary adenoma: think twice about the etiopathogenesis J Endocrinol Invest. 29:750-3, 2006. (1,621) 101) Candeloro P., Borri Voltattorni C., Perniola R, Bertoldi M, Betterle C, Mannelli M, Giordano R, De Bellis A, Tiberti C, Laureti S, Santeusanio F, Falorni A*, and on behalf of the Italian Addison Network. Mapping of human autoantibody epitopes on aromatic l-amino acid decarboxylase. J Clin Endocrinol Metab. ;92(3):1096-105, 2007 (5.873) 102) Brouwers FM, , Elkahloun AG,, Munson PJ, Eisenhofer G, Barb J, Linehan WM, Lenders JWM, De Krijger R, Mannelli M, Udelsman R, Ocal IT, Shulkin BL, Bornstein S, Breza J, Ksinantova L and Pacak K Gene Expression Profiling of Benign and Malignant Pheochromocytoma. Ann N Y Acad Sci. 2006; 1073: 541-54. (1,971) 103) Parenti G, Ricca V, Zogheri A, Serio M, Mannelli M and Peri A. A case of hyponatremia caused by central hypocortisolism. Nat Clin Pract Endocrinol Metab. 3(4):369-75, 2007 (6.702) 104) Bausch B, Borozdin W, Mautner VF, Hoffmann MM, Boehm D, Robledo M, Cascon A, Harenberg T, Schiavi F, Pawlu C, Peczkowska M, Letizia C, Calvieri S, Arnaldi G, Klingenberg-Noftz RD, Reisch N, Fassina A, Brunaud L, Walter MA, Mannelli M, Macgregor G, Palazzo FF, Barontini M, Walz MK, Kremens B, Brabant G, Pfaffle R, Koschker AC, Lohoefner F, Mohaupt M, Gimm O, Jarzab B, McWhinney SR, Opocher G, Januzewicz A, Kohlhase J, Eng C, Neumann HP. Germline NF1 Mutational Spectra and Loss-of-Heterozygosity Analyses in Patients with Pheochromocytoma and Neurofibromatosis Type 1. J Clin Endocrinol Metab.2007; 92: 2784-2792. (5.873). 105) Mannelli M, Simi L, Gagliano MS, Opocher G, Ercolino T, Becherini L, Parenti G. Genetics and biology of pheochromocytoma. Exp Clin Endocrinol Diabetes. 2007; 115:160-5. (1,356) 106) Terzolo M, Angeli A, Fassnacht M, Daffara F, Tauchmanova L, Conton PA Rossetto R, Buci L, Sperone P, Grossrubatscher, Reimondo G, Bollito E, Capotti M, Saeger W, Hahner S, Koschker AC, Arvat E, Ambrosi B, Loli P, Lombardi G, Mannelli M, Bruzzi P, Mantero F, Allolio B, Dogliotti L, Berruti A. Adjuvant mitotane treatment for adrenocortical carcinoma. N Engl J Med.2007; 356:2372-80. (51,296) 107) Mannelli M, Ercolino T, Giachè V, Simi L, Cirami C, Parenti G. Genetic screening for pheochromocytoma: should SDHC gene analysis be included? J Med Genet. 2007;44: 586-587. (5,087) 108) Rossi GP, Belfiore A, Bernini G, Desideri G, Fabris B, Ferri C, Giacchetti G, Letizia C, Maccario M, Mallamaci F, Mannelli M, Montemurro D, Palumbo G, Rizzoni D, Rossi E, Semplicini A, Agabiti-Rosei E, Pessina AC, Mantero F; for the PAPY Study Investigators. Prospective evaluation of the saline infusion test for excluding primary aldosteronism due to aldosterone-producing adenoma. J Hypertens. 25:1433-42; 2007 (4,021) 109) Rossi GP, Belfiore A, Bernini G, Desideri G, Fabris B, Ferri C, Giacchetti G, Letizia C, Maccario M, Mallamaci F, Mannelli M, Palumbo G, Rizzoni D, Rossi E, Agabiti-Rosei E, Pessina AC, Mantero F; for the Primary Aldosteronism Prevalence in Italy Study Investigators. Comparison of the Captopril and the Saline Infusion Test for Excluding Aldosterone-Producing Adenoma. Hypertension. 2007. 50: 424-431 (6,007) 110) Ercolino T, Becherini L, Valeri A, Maiello M, Gaglianò MS, Parenti G, Ramazzotti M, Piscitelli E, Simi L, Pinzani P, Nesi G, Degl'innocenti D, Console N, Bergamini C, Mannelli M Uncommon clinical presentations of pheochromocytoma and paraganglioma in two different patients affected by two distinct novel VHL germline mutations. Clin Endocrinol (Oxf). 2007 68:762-768 (3.412). 111) ErcolinoT, Lombardi A, Becherini L, Piscitelli E, Cantini G, Gaglianò M.S., Serio M, Luconi M, Mannelli M. The Y606C RET mutation causes a receptor gain of function. Clin Endocrinol (Oxf), 2008, 69:253-258 (3.358) 112) Rossi GP, Belfiore A, Bernini G, Fabris B, Caridi G, Ferri C, Giacchetti G, Letizia C, Maccario M, Mannelli M, Palumbo G, Patalano A, Rizzoni D, Rossi E, Pessina AC, Mantero F; the Primary Aldosteronism Prevalence in hYpertension Study Investigators. Body Mass Index Predicts Plasma Aldosterone Concentrations in Overweight-Obese Primary Hypertensive Patients. J Clin Endocrinol Metab. 2008 93:2566-2571 (5,493) 113) Cantini G, Lombardi A, Piscitelli E, Poli G, Ceni E, Marchiani S, Ercolino T, Galli A , Serio M, Mannelli M, and Luconi M. Rosiglitazone Inhibits Adrenocortical Cancer Cell Proliferation by Interfering with the IGF-IR Intracellular Signaling. PPAR Res, 2008; 2008:904041. Epub 2008 Jul 28. (2,727) 114) Ercolino T., C. Taurino , R. Sestini , A.V. Bacca , M. Genuardi , M. Mannelli , and G.P. Bernini. Malignant extra-adrenal pheochromocytoma caused by an SDHB intronic variation leading to a 54-bp deletion in exon 4. J Endocrinol Invest, 2009, 32: 111-114 (2.021) 115) Eisenhofer G, Huynh TT, Elkahloun A, Morris JC, Bratslavsky G, Linehan WM, Zhuang Z, Balgley BM, Lee CS, Mannelli M, Lenders J, Bornstein S, Pacak K. Differential expression of the regulated catecholamine secretory pathway in different hereditary forms of pheochromocytoma. Am J Physiol Endocrinol Metab. 2008, 295: E 1223-1233 (4.138) 116) Timmers H, Gimenez-Roqueplo AP, Mannelli M, Pacak K. Clinical aspects of SDHx-related pheochromocytoma and paraganglioma. Endocr Relat Cancer. 2009, 16: 391-400 (5.193) 117) Mannelli M, Castellano M, Schiavi F, Filetti S, Giacchè M, Mori L, Pignataro V, Bernini GP, Giachè V, Bacca A, Biondi B, Corona G, Di Trapani G, Grossrubatscher E, Reimondo G, Arnaldi G, Giochetti G, Veglio F, Loli P, Colao A, Ambrosio MR, Terzolo M, Letizia C, Ercolino T, Opocher G. Clinically guided genetic screening in a large cohort of Italian patients with pheochromocytomas and/or functional and non-functional paragangliomas. J Clin Endocrinol Metab 2009 , 94: 1541-1547 (6,325) 118) Goffrini P, Ercolino T, Panizza E, Giachè V, Cavone L, Chiarugi A, Dima V, Ferrero I, Mannelli M. Functional study in a yeast model of a novel succinate-dehydrogenase subunit B gene germline missense mutation (C191Y) diagnosed in a patient affected by a glomus tumor. Hum Mol Genet. 2009 18: 1860-1868 (7,249) 119) Mannelli M. Biochemistry, genetics and therapy of malignant pheochromocytomas. Ann Endocrinol (Paris) 2009, 70:166-167 (0,446) 120) Rotondi M, Ercolino T, Fonte R, Lagonigro MS, Leporati P, Villani L, La Manna L, Mannelli M, Chiovato L. Occurrence of medullary thyroid carcinoma, bronchial carcinoid tumor, and papillary thyroid carcinoma in a family bearing the RET G691S polymorphism. J Endocrinol Invest 2009 32:115-118 (2,021) 121) van Nederveen FH, Gaal J, Favier J, Korpershoek E, Oldenburg RA, de Bruyn EM, Sleddens HF, Derkx P, Rivière J, Dannenberg H, Petri BJ, Komminoth P, Pacak K, Hop WC, Pollard PJ, Mannelli M, Bayley JP, Perren A, Niemann S, Verhofstad AA, de Bruïne AP, Maher ER, Tissier F, Méatchi T, Badoual C, Bertherat J, Amar L, Alataki D, Van Marck E, Ferrau F, François J, de Herder WW, Peeters MP, van Linge A, Lenders JW, Gimenez-Roqueplo AP, de Krijger RR, Dinjens WN. An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis. Lancet Oncol. 2009; 10:764-71. (13,283) 122) Lenders JW, Pacak K, Huynh TT, Sharabi Y, Mannelli M, Bratslavsky G, Goldstein DS, Bornstein SR, Eisenhofer G. Low Sensitivity of Glucagon Provocative Testing for Diagnosis of Pheochromocytoma. J Clin Endocrinol Metab 2010; 95: 238-245 (6,325) 123) Rossi GP, Seccia TM, Palumbo G, Belfiore A, Bernini G, Caridi G, Desideri G, Fabris B, Ferri C, Giacchetti G, Letizia C, Maccario M, Mallamaci F, Mannelli M, Patalano A, Rizzoni D, Rossi E, Pessina AC, Mantero F; for the Primary Aldosteronism in the Prevalence in hYpertension (PAPY) Study Investigators Within-Patient Reproducibility of the Aldosterone:Renin Ratio in Primary Aldosteronism. Hypertension 2010; 55: 83-89 (6.007) 124) Luconi M, Mangoni M, Gelmini S, Poli G, Nesi G, Francalanci M, Pratesi N, Cantini G, Lombardi A, Pepi M, Ercolino T, Serio M, Orlando C, Mannelli M. Rosiglitazone impairs proliferation of human adrenocortical cancer: preclinical study in a xenograft mouse model. Endocr Relat Cancer 2010; 17:169-77 (5,236) 125) Gomez-Sanchez CE, Rossi GP, Fallo F, Mannelli M. Progress in Primary Aldosteronism: Present Challenges and Perspectives. Horm Metab Res 2010 42: 374-381 (2,715) 126) Simi L, Malentacchi F, Luciani P, Gelmini S, Deledda C, Arvia R, Mannelli M, Peri A, Orlando C. Seladin-1 expression is regulated by promoter methylation in adrenal cancer. BMC Cancer, 2010 10: 201-208 (2,736) 127) M. Mannelli, G. Cantini, G. Poli, M. Mangoni, G. Nesi, L. Canu, E. Rapizzi, E. Borgogni, T. Ercolino, V. Piccini, M. Luconi. The role of PPAR-γ system in normal and tumoral corticotroph pituitary and adrenal cells. Neuroendocrinology 2010 suppl 1: 23-27. (3,074) 128) Molatore S, Liyanarachchi S, Irmler M, Perren A, Mannelli M, Ercolino T, Beuschlein F, Jarzab B, Wloch J, Ziaja J, Zoubaa S, Neff F, Beckers J, Höfler H, Atkinson MJ, Pellegata NS. Pheochromocytoma in rats with multiple endocrine neoplasia (MENX) shares gene expression patterns with human pheochromocytoma. Proc Natl Acad Sci U S A. 2010 107:18493-8 (9,432). 129) Eisenhofer G, Pacak K, Huynh T, Qin N, Bratslavsky G, Linehan WM, Mannelli M, Friberg P, Grebe S, Timmers H, Bornstein S, Lenders JWM. Catecholamine metabolomic and secretory phenotypes in phaeochromocytoma. Endocr Relat Cancer 2010 18:97-111 (5,236) 130) Mannelli M, Colagrande S, Valeri A, Parenti G. Incidental and metastatic adrenal masses. Semin Oncol 2010 37:649-61 (3,143) 131) Eisenhofer G, Timmers H, Lenders JWM, Bornstein S, Tiebel O, Mannelli M, Bratslavsky G, Vocke K, King K, Pacak K. Age at diagnosis of Pheochromocytoma differs according to cathecolamine phenotype and tumor location. J Clin Endocrinol Metab. 2011, 2: 375-84 (6,325). 132) Yao L, Schiavi F, Cascon A, Qin Y, Inglada-Pérez L, King EE, Toledo RA, Ercolino T, Rapizzi E,. Ricketts CJ, Mori L, Giacchè M, Mendola A, Taschin E, Boaretto F, Loli P, Iacobone M, Rossi GP, Biondi B, Lima-Junior JV, Kater CE, Bex M, Vikkula M, Grossman AB, Gruber SB, Barontini M, Persu A, Castellano M, Toledo SPA, Maher ER, Mannelli M, Opocher G, Robledo M, Dahia PLM. Spectrum and prevalence of FP/TMEM127 gene mutations in pheochromocytomas and paragangliomas. JAMA 2010; 403:2611-9 (28,899) 133) Eisenhofer G, Lenders JW, Timmers H, Mannelli M, Grebe SK, Hofbauer LC, Bornstein SR, Tiebel O, Adams K, Bratslavsky G, Linehan WM, Pacak K. Measurements of Plasma Methoxytyramine, Normetanephrine, and Metanephrine as Discriminators of Different Hereditary Forms of Pheochromocytoma. Clin Chem 2011 57: 411-420 (6,886) 134) Comino-Méndez , Gracia-Aznárez FJ, Schiavi F, Landa I, Leandro-García LJ, Letón R, Honrado E, Ramos-Medina R, Caronia D, Pita G, Gómez-Graña A, de Cubas AA, Inglada-Pérez L, Maliszewska A, Taschin E, Bobisse S, Pica G, Loli P, Hernández-Lavado R, Díaz JA, Gómez-Morales M, González-Neira A, Roncador G, Rodríguez-Antona C, Benítez J, Mannelli M, Opocher G, Robledo M, Cascón A Exome sequencing identifies MAX mutations as a cause of hereditary pheochromocytoma Nat Genet, 2011 43: 663-667 (36,377) 135) Eisenhofer G, Lenders JW, Siegert G, Bornstein SR, Friberg P, Milosevic D, Mannelli M, Linehan WM, Adams K, Timmers HJ, Pacak K. Plasma methoxytyramine: A novel biomarker of metastatic pheochromocytoma and paraganglioma in relation to established risk factors of tumour size, location and SDHB mutation status Eur J Cancer. 2012, 48: 1739-1749 (4.944) 136) Luconi M, Mannelli M. Xenograft models for preclinical drug testing: Implications for adrenocortical cancer. Mol Cell Endocrinol 2012, 351: 71-77 (4.119) 137) Piccini V, Rapizzi E, Bacca A, Di Trapani G, Pulli R, Giachè V, Zampetti B, Lucci-Cordisco E, Canu L, Corsini E, Faggiano A, Deiana L, Carrara D, Tantardini V, Mariotti S, Ambrosio MR, Zatelli MC, Parenti G, Colao A, Pratesi C, Bernini G, Ercolino T, Mannelli M. Head and neck paragangliomas: genetic spectrum and clinical variability in 79 consecutive patients. End Rel Cancer. 2012, 19: 149-155. (5,261) 138) Mannelli M, Lenders JWM, Pacak K, Parenti G, Eisenhofer G. Subclinical Pheochromocytoma. Best Pract Res Cl End. 2012, 26: 507-515 (4.190) 139) Mannelli M, Dralle H, Lenders JWM. Perioperative management of Pheochromocytoma/Paraganglioma: is there a state of the art? Horm Metab Res. 2012, 44: 373-378 (2.414) 140) Rapizzi E, Ercolino T, Canu L, Giachè V, Francalanci M, Pratesi C, Valeri A, Mannelli M. Mitochondrial function and content in Pheochromocytoma/paraganglioma of succinate dehydrogenase mutation carriers. Endocr Relat Cancer 2012, 19:261-269 (5,261) 141) Burnichon N, Cascon A, Schiavi F, Paes Morales N, Comino-Mendez I, Abermil N, Inglada-Perez L, de Cubas AA, Amar L, Barontini MB, Bernaldo de Quiros S, Bertherat J, Bignon YJ, Blok MJ, Bobisse S, Borrego S, Castellano M, Chanson P, Chiara MD, Corssmit EP, Giacche M, de Krijger RR, Ercolino T, Girerd X, Gomez-Garcia EB, Gomez-Grana A, Guilhem I, Hes F, Honrado E, Korpershoek E, Lenders JW, Leton R, Mensenkamp AR, Merlo A, Mori L, Murat A, Pierre P, Plouin PF, Prodanov T, Quesada-Charneco M, Qin N, Rapizzi E, Raymond V, Reisch N, Roncador G, Ruiz-Ferrer M, Schillo F, Stegmann AP, Suarez C, Taschin E, Timmers HJ, Tops C, Urioste M, Beuschlein F, Pacak K, Mannelli M, Dahia PL, Opocher G, Eisenhofer G, Gimenez-Roqueplo AP, Robledo M. MAX mutations cause hereditary and sporadic pheochromocytoma and paraganglioma. Clin Cancer Res 2012, 18: 2828-37 (7.338) 142) Parenti G, Zampetti B, Rapizzi E, Ercolino T, Giachè V, Mannelli M. Updated and new perspective on diagnosis, prognosis and therapy of malignant pheochromocytoma/paraganglioma. J Oncol 2012; 2012: 872713 143) Ramundo V, Ercolino T, Faggiano A, Giachè V, Ragghianti B, Rapizzi E, Colao A, Mannelli M. Genetic-clinical profile of subjects with apparently sporadic extra-adrenal paragangliomas. Front Endocrinol (Lausanne). 2012;3:65. Epub 2012 May 18 144) Abraham WT, Decaux G, Josiassen RC, Yagil Y, Kopyt N, Thacker HP, Mannelli M, Bichet DG, Orlandi C. Oral lixivaptan effectively increases serum sodium concentrations in outpatients with euvolemic hyponatremia. Kidney Int 2012 ; 82:1215-1222 (6.606) 145) Perigli G, Qirici E, Badii B, Kokomani A, Staderini F, Luconi M, Crescioli C, Mannelli M, Maggi M, Cianchi F. Feasibility and safety of minimal-incision thyroidectomy for Graves’ disease. A prospective, sigle-center study. Head & Neck, 2013; 35:1345-1348. (2,833) 146) Panizza E, Ercolino T, Mori L, Rapizzi E, Castellano M, Opocher G, Ferrero I, Neumann HPH, Mannelli M, Goffrini P. Yeast model for evaluating the pathogenic significance of SDHB, SDHC and SDHD mutations in PHEO-PGL syndrome. Hum Mol Genet 2013; 22: 804-815 (7,636) 147) Chortis V, Taylor AE, Schneider P, Tomlinson JW, Hughes BA, O'Neil DM, Libé R, Allolio B, Bertagna X, Bertherat J, Beuschlein F, Fassnacht M, Karavitaki N, Mannelli M, Mantero F, Opocher G, Porfiri E, Quinkler M, Sherlock M, Terzolo M, Nightingale P, Shackleton CHL, Stewart PM, Hahner S, Arlt W. 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J Endocrinol Invest. 2017 2018; 41:499-507 Review 198) Salvianti F, Canu L, Poli G, Armignacco R, Scatena C, Cantini G, Di Franco A, Gelmini S, Ercolino T, Pazzagli M, Nesi G, Mannelli M, Pinzani P, Luconi M. New insights in the clinical and translational relevance of miR483-5p in adrenocortical cancer. Oncotarget 2017 8:65525-65533 199) Rossi GP, Maiolino G, Flego A, Belfiore A, Bernini G, Fabris B, Ferri C, Giacchetti G, Letizia C, Maccario M, Mallamaci F, Muiesan ML, Mannelli M, Negro A, Palumbo G, Parenti G, Rossi E, Mantero F; PAPY Study Investigators. Adrenalectomy Lowers Incident Atrial Fibrillation in Primary Aldosteronism Patients at Long Term. Hypertension 2018 71:585-591. 200) Sparano C, Parenti G, Cilotti A, Bencini L, Calistri M, Mannucci E, Biagini C, Vezzosi V, Mannelli M, Forti G, Petrone L. Clinical impact of the new SIAPEC-IAP classification on the indeterminate category of thyroid nodules. J Endocrinol Invest 2018 Mar 15. doi: 10.1007/s40618-018-0871-7. 201) Calsina B, Currás-Freixes M, Buffet A, Pons T, Contreras L, Letón R, Comino-Méndez I, Remacha L, Calatayud M, Obispo B, Martin A, Cohen R, Richter S, Balmaña J, Korpershoek E, Rapizzi E, Deutschbein T, Vroonen L, Favier J, de Krijger RR, Fassnacht M, Beuschlein F, Timmers HJ, Eisenhofer G, Mannelli M, Pacak K, Satrústegui J, Rodríguez-Antona C, Amar L, Cascón A, Dölker N, Gimenez-Roqueplo AP, Robledo M. Role of MDH2 pathogenic variant in pheochromocytoma and paraganglioma patients. Genet Med. 2018 Jul 16. doi: 10.1038/s41436-018-0068-7. [Epub ahead of print] 202) Richter S, Gieldon L, Pang Y, Peitzsch M, Huynh T, Leton R, Viana B, Ercolino T, Mangelis A, Rapizzi E, Menschikowski M, Aust D, Kroiss M, Beuschlein F, Gudziol V, Timmers HJ, Lenders J, Mannelli M, Cascon A, Pacak K, Robledo M, Eisenhofer G, Klink B. Metabolome-guided genomics to identify pathogenic variants in isocitrate dehydrogenase, fumarate hydratase, and succinate dehydrogenase genes in pheochromocytoma and paraganglioma. Genet Med. 2018 Jul 27. doi: 10.1038/s41436-018-0106-5. [Epub ahead of print] 203) Richter S, D'Antongiovanni V, Martinelli S, Bechmann N, Riverso M, Poitz DM, Pacak K, Eisenhofer G, Mannelli M, Rapizzi E. Primary fibroblast co-culture stimulates growth and metabolism in Sdhb-impaired mouse pheochromocytoma MTT cells. Cell Tissue Res. 2018 Aug 29. doi: 10.1007/s00441-018-2907-x. [Epub ahead of print] 204) Poli G, Sarchielli E, Guasti D, Benvenuti S, Ballerini L, Mazzanti B, Armignacco R, Cantini G, Lulli M, Chortis V, Arlt W, Romagnoli P, Vannelli GB, Mannelli M, Luconi M. Human fetal adrenal cells retain age-related stem- and endocrine-differentiation potential in culture. FASEB J. 2018 Sep 24:fj201801028RR. doi: 10.1096/fj.201801028RR. [Epub ahead of print]
  • Premi e riconoscimenti

    • Premio della 39th Helen and Payne Whitney Lecturship in Medicine, North Shore Long Island JewishMedical Center, North Shore University Hospital, NY, 2008.
    • Membro dell' International Organizing Committee of the 1st Intern. Symposium on Pheochromocytoma, NIH, Washington, October 2005
    • Membro dell' International Organizing Committee of the 2nd Intern. Symposium on Pheochromocytoma, Cambridge, UK, September 2008
    • Membro dello Scientific Board of the International Symposium on Adrenal Tumors, Padova, September 2009
    • Membro dell' International Organizing Committee of the 3rd Intern. Symposium on Pheochromocytoma, Paris, France, September 2011
    • Membro dell' International Organizing Committee of the 4th Intern. Symposium on Pheochromocytoma, Kyoto, Japan, Sept 2014
    • Membro dell' International Organizing Committee of the 5th Intern. Symposium on Pheochromocytoma, Sydney, Australia, Sept 2017
    • Relatore Invitato: 5th International Conference on Peripheral Dopamine, 1994 Kyoto (Japan):
    • Relatore Invitato: 8th International Catecholamine Symposium, 1996 Asilomar (USA)
    • Relatore invitato: 7th International Workshop on Multiple Endocrine Neoplasia, 1999 Gubbio (Italy)
    • Relatore Invitato: 14th EFES Postgraduate Course in Clinical Endocrinology: Adrenal Cancer, 2005 Naples (Italy)
    • Relatore invitato: European Congress of Endocrinology, 2006 Glasgow (Ireland)
    • Relatore invitato: European Congress of Endocrinology, 2007 Budapest (Hungary)
    • Relatore invitato: European Congress of Endocrinology, 2009 Istanbul (Turkey)
    • Relatore invitato: 52eme Journees Internationales Henri-Pierre Klotz, 2009 Paris (France)
    • ENDO Society 2012 Lecture: New Genes Mutations in Pheochromocytoma, 2012 Houston (USA)
    • ENDO Society 2013 Meet-the-Professor Session: Pheochromocytoma, 2013 San Francisco (USA)
    • ENEA 2014 Lecture Molecular Targets in Pheochromocytoma, 2014 Sophia (Rumania)
    • European Congress of Endocrinology. Lecture Pheochromocytoma and paraganglioma during Pregnancy, Wroclaw (Poland) 2014
    • ENDO Society 2017: lecture: SDHX mutations: beyond pheochromocytomas / paragangliomas, 2017 Orlando (USA)

 Patologie, Esami e Trattamenti

  • Disturbi della ghiandola tiroidea
  • Disturbi delle ghiandole surrenali
  • Ipofisi
  • Termoablazione
  • Tiroide
  • Tumore alla tiroide
  • Tumore Surrene

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Che cos’è il Feocromocitoma?

Il Feocromocitoma è un tumore spesso generato da un’anomalia genetica, che si può presentare anche in forma multipla e può colpire anche più membri dello stesso nucleo familiare. Ce ne parla il Prof. Massimo Mannelli, esperto in Endocrinologia a Firenze.

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